FIIN-3

SKU: orb1223253

Description

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R.

Key Properties

• CAS Number: 1637735-84-2
• MW: 691.61
• Purity: >98% (HPLC)
• Formula: C₃₄H₃₆Cl₂N₈O₄
• SMILES: C(=O)(C=C)Nc1ccc(cc1)CN(c1ncnc(c1)Nc1ccc(cc1)N1CCN(CC1)C)C(=O)Nc1c(c(cc(c1Cl)OC)OC)Cl
• Target: Sirtuin
• Solubility: DMSO : 10 mg/mL 14.46 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FIIN3 | FIIN 3 | FIIN-3

Quick Database Links

Gene Symbol

Sirtuin