Galunisertib

SKU: orb1305376

Description

Galunisertib (LY2157299) is a selective TGF-β receptor type I inhibitor (IC50=56 nM) with demonstrated antitumor activity. It is widely used in oncology research, particularly in studies exploring its mechanism in vitro and its efficacy in combination with immune checkpoint inhibitors like anti-PD-1 antibodies in vivo tumor models.

Research Area

Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 700874-72-2
• MW: 369.4
• Purity: >98%
• Formula: C₂₂H₁₉N₅O
• SMILES: Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O
• Target: Kinase
• Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY2157299

Quick Database Links

Gene Symbol

Kinase