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Gambogic acid

SKU: orb1301000

Description

Gambogic Acid is a natural small molecule that induces apoptosis by potently inhibiting anti-apoptotic Bcl-2 family proteins (Bcl-2, Bcl-XL, Mcl-1, etc.) and activating caspases (EC50 0.78-1.64 µM). It is widely used in cancer research, demonstrating antitumor activity in both cellular and animal models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2752-65-0
MW628.75
Purity>98%
FormulaC38H44O8
SMILESCC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(O)=C2C=C1)C(=O)C1=CC2CC4C(C)(C)OC(C\C=C(/C)C(O)=O)(C2=O)C14O3
TargetAutophagy,Bcl-2 Family
SolubilitySoluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 50 mg/ml)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

β-Guttiferrin, Beta-Guttiferrin, Autophagy, b-Guttiferrin, Bfl-1, Bcl-w, Bcl-B, Bcl-2, Bcl-2 Family, Inhibitor, Mcl-1, Guttatic Acid, Guttic Acid, Gambogic Acid, inhibit

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Gambogic acid (orb1301000)

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5 mg
$ 190.00
25 mg
$ 400.00
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