GC376

SKU: orb1302013

Description

GC376 is a potent small molecule inhibitor of 3C-like proteases (3CLpro), exhibiting inhibitory activity in the low micromolar range (IC50 0.49-4.35 µM). It is widely used in biochemical and cellular assays to study coronavirus replication and has demonstrated antiviral efficacy in feline infectious peritonitis models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1416992-39-6
• MW: 507.53
• Purity: >95%
• Formula: C₂₁H₃₀N₃NaO₈S
• SMILES: [Na+].[H][C@@](CC1CCNC1=O)(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(O)S([O-])(=O)=O
• Target: Protease
• Solubility: DMSO:45 mg/mL (88.66 mM);5% DMSO+95% Saline:2.25 mg/mL (4.43 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3CLpro, GC376 sodium, GC-376 sodium, SARSCoV

Quick Database Links

Gene Symbol

Protease