Genz-123346 free base

SKU: orb1223113

Description

Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

Key Properties

• CAS Number: 491833-30-8
• MW: 418.57
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₈N₂O₄
• SMILES: C(=O)(CCCCCCCC)N[C@@H]([C@H](O)c1cc2c(OCCO2)cc1)CN1CCCC1
• Target: Gamma-secretase
• Solubility: DMSO : ≥ 100 mg/mL; 238.91 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Genz123346 | Genz-123346 | Genz 123346

Quick Database Links

Gene Symbol

Gamma-secretase