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GNF-7

SKU: orb1223895

Description

A potent and selective type-II kinase inhibitor of Bcr-Abl; inhibits wt Bcr-Abl/T315I Bcr-Abl (IC50< 5 nM) and Bcr-Abl mutants such as G250E, Q252H, Y253H, E255K, E255V, F317L, and M351T in biochemical and cellular assays; displays in vivo efficacy against T315I-Bcr-Abl in xenograft mouse model.

Images & Validation

Key Properties

CAS Number839706-07-9
MW547.5311
Purity>98% (HPLC)
FormulaC28H24F3N7O2
SMILESO=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
TargetBcr-Abl
SolubilityDMSO: ≥ 33 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNF 7 | GNF7

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GNF-7 (orb1223895)

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