GNF179

SKU: orb1308264

Description

GNF179 is an optimized 8,8-dimethyl isoprenoid analog demonstrating potent antimalarial activity against multidrug-resistant Plasmodium falciparum (W2 strain, IC50 = 4.8 nM). It exhibits favorable in vitro metabolic stability and oral bioavailability in vivo, supporting its use as a chemical probe for parasitology and antimalarial drug discovery research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1261114-01-5
• MW: 427.9
• Purity: 97.80% (May vary between batches)
• Formula: C₂₂H₂₃ClFN₅O
• SMILES: CC1(C)N(CCn2c(Nc3ccc(Cl)cc3)c(nc12)-c1ccc(F)cc1)C(=O)CN
• Target: Parasite
• Solubility: DMSO:120 mg/mL (280.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.35 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GNF 179, GNF-179, GNF179, Inhibitor, Parasite, inhibit

Quick Database Links

Gene Symbol

Parasite