GNF351

SKU: orb1308262

Description

GNF351 is a potent and selective aryl hydrocarbon receptor (AHR) antagonist, effectively inhibiting both DRE-dependent and -independent signaling with an IC50 of 62 nM. It exhibits low cytotoxicity in keratinocytes and is a valuable research tool for studying AHR biology in inflammatory, toxicological, and oncological contexts, both in vitro and in vivo.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1227634-69-6
• MW: 411.5
• Purity: 98.43% (May vary between batches)
• Formula: C₂₄H₂₅N₇
• SMILES: CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1
• Target: Aryl Hydrocarbon Receptor
• Solubility: DMSO:124 mg/mL (301.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.72 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GNF 351, GNF351, GNF-351, Inhibitor, inhibit, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, aryl hydrocarbon receptor, AhR

Quick Database Links

Gene Symbol

Aryl Hydrocarbon Receptor