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GS-444217

SKU: orb1302011

Description

GS-444217 is a potent and selective ATP-competitive inhibitor of ASK1 (apoptosis signal-regulating kinase 1), exhibiting an IC50 of 2.87 nM. This small molecule is a valuable research tool for investigating the role of ASK1 in cellular stress responses, inflammation, and fibrotic diseases in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1262041-49-5
MW411.46
Purity99.08% (May vary between batches)
FormulaC23H21N7O
SMILESO=C(Nc1cccc(c1)-c1nncn1C1CC1)c1cc(ccn1)-n1cnc(c1)C1CC1
TargetApoptosis,ASK,MAPK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.86 mM);DMSO:55 mg/mL (133.67 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, ASK1, MAP3K, MAP kinase kinase kinase, MEKK, MAPKKK, Inhibitor, GS 444217, GS444217, GS-444217, inhibit

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  • GS-444217 [orb1226648]

    >98% (HPLC)

    1262041-49-5

    411.469

    C23H21N7O

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Protocol Information

GS-444217 (orb1302011)

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Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 180.00
25 mg
$ 270.00
50 mg
$ 440.00
100 mg
$ 640.00
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