GSK805

SKU: orb1299864

Description

GSK805 is a potent, selective, and orally active RORγt inverse agonist with demonstrated blood-brain barrier penetration. It is a valuable research tool for investigating Th17-driven biology in both cellular assays and animal models of autoimmune and inflammatory diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1426802-50-7
• MW: 532.36
• Purity: ≥95% (May vary between batches)
• Formula: C₂₃H₁₈Cl₂F₃NO₄S
• SMILES: CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
• Target: ROR
• Solubility: DMSO:100 mg/mL (187.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (18.78 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CNS penetrant, Inhibitor, inhibit, oral, immunity, GSK805, GSK-805, GSK 805, ROR, RORγt, Th17 cell, RAR-related orphan receptor

Quick Database Links

Gene Symbol

ROR