HA15

SKU: orb1300404

Description

HA15 is a selective BiP/GRP78 inhibitor with demonstrated anti-cancer activity against melanoma, including patient-derived and therapy-resistant cells. It has shown efficacy in both in vitro cell culture and in vivo xenograft models, making it a valuable research tool for studying ER stress and oncology.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1609402-14-3
• MW: 466.58
• Purity: 98.00% (May vary between batches)
• Formula: C₂₃H₂₂N₄O₃S₂
• SMILES: CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1cccc(c1)-c1csc(NC(C)=O)n1
• Target: HSP,Apoptosis,GPCR,Autophagy
• Solubility: DMSO:115 mg/mL (246.47 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.07 mM);Ethanol:42 mg/mL (90.02 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Apoptosis, BiP, inhibit, HSP, HA 15, HA15, HA-15, HSPA5, GRP78, Inhibitor, Heat shock proteins

Quick Database Links

Gene Symbol

HSP,Apoptosis,GPCR,Autophagy