HALOFUGINONE LACTATE

SKU: orb1298633

Description

Halofuginone lactate, a halogenated derivative of the natural compound febrifugine, is a potent and specific inhibitor of prolyl-tRNA synthetase (Ki=18.3 nM). It suppresses type-I collagen synthesis and TGF-β activity, making it a valuable research tool for studying fibrosis, osteoarthritis, and related pathways in both cellular and animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 82186-71-8
• MW: 504.8
• Purity: 99.02% (May vary between batches)
• Formula: C₁₉H₂₃BrClN₃O₆
• SMILES: CC(O)C(O)=O.O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3
• Target: DNA/RNA Synthesis,Calcium Channel,TGF-beta/Smad,Sodium Channel,Parasite
• Solubility: DMSO:22.5 mg/mL (44.57 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, HALOFUGINONE LACTATE, HALOFUGINONE Lactate, prolyl-tRNA synthetase, RNASynthesis, RNA Synthesis, Smad, TGF-β/Smad, TGF-β, TGFβ, TGFbeta/Smad, TGF-beta, TGF-b/Smad, TGFbeta, TGFb

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,Calcium Channel,TGF-beta/Smad,Sodium Channel,Parasite