I-CBP112 hydrochloride

SKU: orb1303026

Description

I-CBP112 is a potent and selective small molecule inhibitor of the CBP/p300 bromodomains. It reduces the leukemia-initiating potential of MLL-AF9+ AML cells in vitro and in vivo and shows synergistic effects with BET inhibitors like JQ1 and chemotherapeutics such as doxorubicin in oncology research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2147701-33-3
• MW: 505.05
• Purity: 97.98% (May vary between batches)
• Formula: C₂₇H₃₇ClN₂O₅
• SMILES: O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl
• Target: Epigenetic Reader Domain
• Solubility: DMSO:60 mg/mL (118.8 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBP/p300, Leukemia cell, CBP/p300, Prostate cancer cell, Inhibitor, I-CBP 112 Hydrochloride, I-CBP112, ICBP112 hydrochloride, I-CBP112 Hydrochloride, I-CBP-112 hydrochloride, I-CBP-112 Hydrochloride, I CBP112 hydrochloride, Epigenetic Reader Domain, EpigeneticReaderDomain, inhibit

Quick Database Links

Gene Symbol

Epigenetic Reader Domain