Imiquimod

SKU: orb1223472

Description

Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin Y called superficial basal cell carcinoma. (In Vivo):In animal models, Imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 99011-02-6
• MW: 240.31
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆N₄
• SMILES: NC1=NC2=CC=CC=C2C3=C1N=CN3CC(C)C
• Target: TLR
• Solubility: DMSO: 0.01 mg/mL (0.04 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R-837 | S-26308 | TMX 101

Quick Database Links

Gene Symbol

TLR