Irinotecan HCl

SKU: orb1310567

Description

Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) is a topoisomerase I inhibitor that stabilizes the DNA-enzyme complex, preventing DNA religation and causing lethal double-strand breaks. It is widely used in cancer research for studying chemotherapy mechanisms and efficacy in both cellular and animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 136572-09-3
• MW: 586.69 ∙ 36.46 ∙ 54.05
• Purity: >98%
• Formula: C₃₃H₃₈N₄O₆ ∙ HCl ∙ 3H₂₀
• SMILES: O.O.O.Cl.CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OC(=O)N3CCC(CC3)N3CCCCC3)cc12
• Target: Topoisomerase
• Solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Topo I, Topoisomerase, Autophagy, (+)-Irinotecan hydrochloride, CPT-11 hydrochloride, CPT-11 HCl, CPT-11 HCl Trihydrate, inhibit, Irinotecan HCl, Irinotecan HCl Trihydrate, Irinotecan hydrochloride, Irinotecan Hydrochloride, Irinotecan hydrochloride trihydrate, Irinotecan hydrochloride Trihydrate, Inhibitor

Quick Database Links

Gene Symbol

Topoisomerase