Isosilybin A

SKU: orb1297319

Description

Isosilybin A is a partial PPARγ agonist that upregulates ABCA1 expression and inhibits tyrosinase activity. It exhibits anti-angiogenic and anti-prostate cancer properties through cell cycle arrest and apoptosis, making it a candidate for research in oncology, dermatology, and metabolic studies.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 142796-21-2
• MW: 482.44
• Purity: 98.00% (May vary between batches)
• Formula: C₂₅H₂₂O₁₀
• SMILES: COc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
• Target: ABC Transporter,Androgen Receptor,ERK,p38 MAPK,NF-κB,Apoptosis,PPAR,Tyrosinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.84 mM);DMSO:90 mg/mL (186.55 mM)

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPARγ, Tyrosinase, inhibit, Isosilybin A, Inhibitor, ABCA1, Apoptosis

Quick Database Links

Gene Symbol

ABC Transporter,Androgen Receptor,ERK,p38 MAPK,NF-κB,Apoptosis,PPAR,Tyrosinase