IU-1

SKU: orb1225335

Description

IU-1 (USP14 inhibitor IU1) is a specific, small molecule inhibitor of deubiquitinating enzyme USP14 with IC50 of 4-5 uM; displays no activity against other human eight DUBs (Uch37, Uch-L1/L3, USP7, etc.); enhances proteasomal degradation in vivo, attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; also inhibits Dengue virus replication.(In Vitro):Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae.

Key Properties

• CAS Number: 314245-33-5
• MW: 300.377
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₁FN₂O
• SMILES: CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3
• Target: DUB
• Solubility: DMSO: 30 mg/mL (100 mM); Ethanol: 15 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP14 inhibitor IU1

Quick Database Links

Gene Symbol

DUB