Ixabepilone

SKU: orb1300396

Description

Ixabepilone is an orally available microtubule-stabilizing agent that binds tubulin, inducing polymerization, G2-M phase arrest, and apoptosis. It is widely used in cancer research, demonstrating activity in both in vitro cell-based assays and in vivo tumor models for studying chemotherapeutic mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 219989-84-1
• MW: 506.7
• Purity: 98.00% (May vary between batches)
• Formula: C₂₇H₄₂N₂O₅S
• SMILES: C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](NC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1
• Target: Microtubule Associated,Antibacterial,Apoptosis
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:250 mg/mL (493.39 mM);Ethanol:93 mg/mL (183.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.51 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Azaepothilone B, Aza-epothilone B, BMS 247550, BMS 247550-1, BMS247550, BMS-247550, Ixempra, Ixabepilone, inhibit, Inhibitor, MicrotubuleAssociated, Microtubule Associated, Microtubule/Tubulin

Quick Database Links

Gene Symbol

Microtubule Associated,Antibacterial,Apoptosis