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JG-98

SKU: orb1226234

Description

JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively); strongly affects autophagic flux, increases p62 oligomerization and reduces p62 monomer; destabilizes FoxM1 and relieved suppression of downstream effectors, including p21 and p27.

Images & Validation

Key Properties

CAS Number1456551-16-8
MW534.532
Purity>98% (HPLC)
FormulaC24H21Cl2N3OS3
SMILESCCN1C(=CC2=[N+](C=CS2)CC3=CC=CC=C3)SC(=C4N(C5=C(S4)C=C(C=C5)Cl)C)C1=O.[Cl-]
TargetHSP
SolubilityDMSO: Soluble ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JG98

Similar Products

  • JG-98 [orb1301863]

    99.13% (May vary between batches)

    1456551-16-8

    534.53

    C24H21Cl2N3OS3

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JG-98 (orb1226234)

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200 mg
500 mg
2 mg
$ 250.00
5 mg
$ 420.00
10 mg
$ 670.00
25 mg
$ 1,070.00
50 mg
$ 1,510.00
100 mg
$ 2,050.00