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Juglone

SKU: orb1221220

Description

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.

Images & Validation

Key Properties

CAS Number481-39-0
MW174.15
Purity>98% (HPLC)
FormulaC10H6O3
SMILESOc1cccc2C(=O)C=CC(=O)c12
TargetDNA/RNA Synthesis
SolubilityDMSO: 15 mg/mL;Ethanol: 15 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Regianin | 5-Hydroxy-14-naphthoquinone

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  • Juglone [orb1303312]

    98.73% (May vary between batches)

    481-39-0

    174.15

    C10H6O3

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Juglone (orb1221220)

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