KW-2478

SKU: orb1300660

Description

KW-2478 is a potent small molecule inhibitor of HSP90 with an IC50 of 3.8 nM. It is a non-ansamycin compound used in cancer research to study oncogenic client protein degradation in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 819812-04-9
• MW: 574.66
• Purity: 98.68% (May vary between batches)
• Formula: C₃₀H₄₂N₂O₉
• SMILES: CCc1c(O)cc(O)c(C(=O)c2ccc(OCCN3CCOCC3)c(OC)c2)c1CC(=O)N(CCOC)CCOC
• Target: HSP
• Solubility: Ethanol:3 mg/mL (5.22 mM);DMSO:106 mg/mL (184.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.7 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Heat shock proteins, Inhibitor, HSP, HSP90, inhibit, KW 2478, KW2478, KW-2478

Quick Database Links

Gene Symbol

HSP