LDN-212854

SKU: orb1307185

Description

LDN-212854 is a selective BMP pathway inhibitor with high potency against ALK2 (IC50=1.3 nM) and distinct activity profiles towards ALK1 and ALK3. It is a valuable research tool for studying BMP signaling in vitro and has been used in vivo to investigate bone formation, heterotopic ossification, and iron metabolism pathways.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1432597-26-6
• MW: 406.48
• Purity: 98.00% (May vary between batches)
• Formula: C₂₅H₂₂N₆
• SMILES: C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12
• Target: ALK,TGF-beta/Smad
• Solubility: DMSO:10.42 mg/mL (25.63 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TGF-β/Smad, TGF-β Receptor, TGFβ, TGFbeta/Smad, TGFb, TGF-b/Smad, TGFbeta, TGF-beta, Transforming growth factor beta receptors, Smad, Huh7, FOP model, EpCAM, heterotopic ossification, HCC, LDN 212854, LDN212854, LDN-212854, MT cell, inhibit, Inhibitor, ALK2, ALK1, ALK3, ALK4, ALK5, BMP, BMP Inhibitor III, BMP9-ID1 signaling, BMPR2 cell

Quick Database Links

Gene Symbol

ALK,TGF-beta/Smad