Leflunomide

SKU: orb1309564

Description

Leflunomide (HWA486) is a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid and psoriatic arthritis. Its active metabolite, teriflunomide, inhibits dihydroorotate dehydrogenase (DHODH), suppressing pyrimidine synthesis in proliferating lymphocytes. This mechanism is validated in both in vitro cellular assays and in vivo animal models of autoimmune disease.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 75706-12-6
• MW: 270.21
• Purity: >98%
• Formula: C₁₂H₉F₃N₂O₂
• SMILES: CC1=C(C=NO1)C(=O)NC1=CC=C(C=C1)C(F)(F)F
• Target: Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RS-34821

Quick Database Links

Gene Symbol

Dehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)