Lopinavir

SKU: orb1307985

Description

Lopinavir (ABT-378) is a peptidomimetic inhibitor of HIV-1 protease that maintains efficacy against the Val82 mutant variant and exhibits reduced serum protein binding compared to ritonavir. It is widely used in antiviral research for in vitro enzyme assays and in vivo studies of HIV infection and resistance mechanisms.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 192725-17-0
• MW: 628.8
• Purity: 98.00% (May vary between batches)
• Formula: C₃₇H₄₈N₄O₅
• SMILES: [C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(COC3=C(C)C=CC=C3C)=O)O)=O)([C@@H](C)C)N4C(=O)NCCC4
• Target: SARS-CoV,HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.36 mM);DMSO:247.5 mg/mL (393.61 mM);Ethanol:116 mg/mL (184.48 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

coadministration, ABT378, ABT-378, ABT 378, infection, inhibit, mutant, Lopinavir, Inhibitor, Human immunodeficiency virus, HIV protease, HIVProtease, HIV Protease, HIV, SARS-CoV, SARS coronavirus, SARSCoV, replication, wild-type

Quick Database Links

Gene Symbol

SARS-CoV,HIV Protease