Lorlatinib

SKU: orb1304578

Description

Lorlatinib (PF-6463922) is a potent, orally bioavailable small molecule inhibitor targeting ALK and ROS1 tyrosine kinases. It is widely used in preclinical oncology research to investigate resistance mechanisms and evaluate antitumor efficacy in both cellular assays and animal models of non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1454846-35-5
• MW: 406.41
• Purity: 99.77% (May vary between batches)
• Formula: C₂₁H₁₉FN₆O₂
• SMILES: C[C@H]1Oc2cc(cnc2N)-c2c(CN(C)C(=O)c3ccc(F)cc13)nn(C)c2C#N
• Target: Apoptosis,Tyrosine Kinases,ROS,ROS Kinase,ALK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM);Ethanol:40.6 mg/mL (99.9 mM);DMSO:13 mg/mL (31.99 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cluster of differentiation 246, CD246, ALK, ALK (L1196M), ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase (ALK), Apoptosis, brain-penetrant, Carcinoma, NSCLC, Neuroblastoma, LTK (TYK1), Lorlatinib, Loratinib, kinase, inhibit, mutation, Inhibitor, PF-6463922, PF6463922, PF 6463922, PF06463922, PF-06463922, PF 06463922, third-generation, ROS, ROS1, ROSKinase, ROS Kinase, TyrosineKinases, Tyrosine Kinases, tyrosine

Quick Database Links

Gene Symbol

Apoptosis,Tyrosine Kinases,ROS,ROS Kinase,ALK