Luminespib

SKU: orb1306830

Description

Luminespib (VER-52296) is a potent and selective HSP90 inhibitor targeting both HSP90α and HSP90β isoforms. It demonstrates significant antitumor activity in preclinical studies, including in vitro cell-based assays and in vivo models for head and neck squamous cell carcinoma and other malignancies.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 747412-49-3
• MW: 465.5
• Purity: >99%
• Formula: C₂₆H₃₁N₃O₅
• SMILES: CCNC(=O)c1noc(c1-c1ccc(CN2CCOCC2)cc1)-c1cc(C(C)C)c(O)cc1O
• Target: HSP (Heat shock protein)
• Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NVP-AUY922; VER-52296

Structure of Luminespib.

Quick Database Links

Gene Symbol

HSP (Heat shock protein)

Mohammed Fulayyih Aloufi et al. Luminespib protects against dexamethasone-induced hepatic, vascular, and metabolic abnormalities in rats Naunyn Schmiedebergs Arch Pharmacol, (2025)

PubMed: 41273382