Lurasidone

SKU: orb1306396

Description

Lurasidone (SM-13496) is a small molecule acting as a dopamine D2 and 5-HT7 receptor antagonist, with respective IC50 values of 1.68 nM and 0.495 nM, and as a 5-HT1A receptor partial agonist (IC50=6.75 nM). It is widely used in preclinical research for studying schizophrenia and mood disorders, employing both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 367514-87-2
• MW: 492.68
• Purity: 99.50% (May vary between batches)
• Formula: C₂₈H₃₆N₄O₂S
• SMILES: O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(CC1)c1nsc2ccccc12
• Target: 5-HT Receptor,Dopamine Receptor
• Solubility: DMSO:17.83 mg/mL (36.19 mM);10% DMSO+90% Corn Oil:1.5 mg/mL (3.04 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT Receptor, 5-HT1A, 5HT Receptor, 5HTReceptor, 5-HT7, 5-hydroxytryptamine Receptor, D2, Dopamine, Dopamine Receptor, DopamineReceptor, inhibit, Lurasidone, Inhibitor, SM13496, SM-13496, SM 13496, Serotonin Receptor

Quick Database Links

Gene Symbol

5-HT Receptor,Dopamine Receptor