Macitentan

SKU: orb1305317

Description

Macitentan (ACT-064992) is a dual endothelin receptor antagonist employed in pulmonary arterial hypertension (PAH) research. It is widely used in both in vitro binding assays and in vivo animal models to study endothelin signaling pathways and evaluate potential therapeutic interventions.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 441798-33-0
• MW: 588.27
• Purity: 98.00% (May vary between batches)
• Formula: C₁₉H₂₀Br₂N₆O₄S
• SMILES: N(S(NCCC)(=O)=O)C=1C(=C(OCCOC=2N=CC(Br)=CN2)N=CN1)C3=CC=C(Br)C=C3
• Target: Apoptosis,Endothelin Receptor
• Solubility: DMSO:93 mg/mL (158.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.61 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arterial, Apoptosis, ACT064992, ACT-064992, ACT 064992, Inhibitor, hypertension, idiopathic, endothelin, Endothelin Receptor, EndothelinReceptor, ET-B, ETB, ET-A, ETA, fibrosis, inhibit, non-peptide, orally, Macitentan, pulmonary

Quick Database Links

Gene Symbol

Apoptosis,Endothelin Receptor