Mant-AppNHp

SKU: orb63431

Description

(Mant-AMPPNP)

Images & Validation

• Application Notes:
  Fluorescence stop-flow kinetics: helicase DnaB protein Displacement studies on TRP-MET-tyrosine kinase Nucleotide specific binding to membrane protein FeoB Inhibition of adenylyl cyclase X-ray studies of kinesin motors Agonistic ligand, mainly for nucleoside receptor A 1 Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors. ; Spectroscopic Propertie: λmax 255/355 nm, ε 23.3/5.8 L mmol-1 cm-1, (Tris-HCl pH 7.5), λexc 355 nm, λem 448 nm. ; Specific Ligands: ATP-binding sites of serine protease, (10S)-myosin.

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Key Properties

• CAS Number: 85287-56-6
• MW: Theoretical MW: 639.35 g/mol (free acid); Detected MW: 639.06 g/mol (free acid)
• Purity: ≥ 90% (HPLC)
• Formula: C₁₈H₂₄N₇O₁₃P₃
• SMILES: OP(=O)(O)NP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc23)[C@H](OC(=O)c2c(cccc2)NC)[C@@H]1O.OP(=O)(O)NP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc23)[C@H](O)[C@@H]1OC(=O)c1c(cccc1)NC

Storage & Handling

• Storage: store at -20 °C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Mant-AMPPNP), 2'/3'-O-(N-Methyl-anthraniloyl)-adenosine-5'-[(β,γ)-imido]-triphosphate, Triethylammonium salt

Wang, Juncheng et al. Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance Mol Cell, (2022)

PubMed: 35202575