MC-Val-Cit-PAB

SKU: orb1302049

Description

MC-Val-Cit-PAB is a protease-cleavable linker utilized in the construction of antibody-drug conjugates (ADCs), such as the clinically approved brentuximab vedotin. It enables targeted drug delivery and release in both in vitro and in vivo research models for oncology and targeted therapy development.

Research Area

Neuroscience, Signal Transduction

Key Properties

• CAS Number: 159857-80-4
• MW: 572.65
• Purity: 98.03% (May vary between batches)
• Formula: C₂₈H₄₀N₆O₇
• SMILES: [C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CO)C=C2)=O)CCCNC(N)=O
• Target: ADC Linker,AChR
• Solubility: DMSO:22 mg/mL (38.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.73 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, MCValCitPAB, MC-Val-Cit-PAB, MC Val Cit PAB, Antibody-drug conjugates linkers, ADCLinker, ADC Linker, ADC Linkers

Quick Database Links

Gene Symbol

ADC Linker,AChR