Methotrexate

SKU: orb1308506

Description

Methotrexate is a folate analog and potent inhibitor of dihydrofolate reductase (DHFR), exhibiting antimetabolic and immunosuppressive properties. It is widely used in research areas including oncology, immunology, and rheumatology for in vitro cell-based assays and in vivo disease modeling.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59-05-2
• MW: 454.44
• Purity: 96.84% (May vary between batches)
• Formula: C₂₀H₂₂N₈O₅
• SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
• Target: ADC Cytotoxin,Dehydrogenase,Apoptosis,DNA/RNA Synthesis,Antifolate
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:8.3 mg/mL (18.26 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:70 mg/mL (154.04 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arthritis, antineoplastic, Apoptosis, Antifolate, Amethopterin, ADC Payload, ADC Cytotoxin, ADCCytotoxin, DNA, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, CL 14377, CL14377, CL-14377, immunosuppressant, inhibit, lymphoblastic, Methotrexate, NCI-C 04671, NCI-C04671, NCI-C-04671, Inhibitor, hDHFR(dihydrofolate reductase), leukemia, WR19039, WR-19039, WR 19039, reductase, RNA Synthesis, RNASynthesis, rheumatoid, synthesis

Quick Database Links

Gene Symbol

ADC Cytotoxin,Dehydrogenase,Apoptosis,DNA/RNA Synthesis,Antifolate