PD-325901

SKU: orb1300996

Description

Mirdametinib (PD325901) is a potent, selective, and orally active non-ATP-competitive MEK inhibitor (IC50=0.33 nM). It demonstrates antitumor activity in research models by suppressing p-ERK1/2 and promoting apoptosis, making it a valuable tool for studying MAPK/ERK pathway dysregulation in cancer, both in vitro and in vivo.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 391210-10-9
• MW: 482.20
• Purity: > 98%
• Formula: C₁₆H₁₄F₃IN₂O₄
• SMILES: OC[C@@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F
• Target: Kinase
• Solubility: Soluble in DMSO (up to 12 mg/ml)

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Apoptosis, inhibit, Mitogen-activated protein kinase kinase, Mirdametinib, PD325901, PD-325901, PD0325901, PD-0325901, PD 0325901, PD 325901, Inhibitor, MAP2K, MAPKK, MEK

Quick Database Links

Gene Symbol

Kinase