ML-180

SKU: orb1219596

Description

ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling. ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue.

Key Properties

• CAS Number: 863588-32-3
• MW: 388.89
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₅ClN₄O₂
• SMILES: Clc1cccc(c1)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1
• Target: orphan nuclear receptor NR5A2
• Solubility: DMSO:11 mg/mL (28.28 mM; Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SR1848

Quick Database Links

Gene Symbol

orphan nuclear receptor NR5A2