ML382

SKU: orb1220019

Description

ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects. Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist.

Key Properties

• CAS Number: 1646499-97-9
• MW: 360.42
• Purity: >98% (HPLC)
• Formula: C??H??NO?
• SMILES: CCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1
• Target: MrgX1
• Solubility: In Vitro: DMSO : 100 mg/mL (277.45 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MrgX1