Motolimod

SKU: orb1300365

Description

Motolimod (VTX-378/VTX-2337) is a potent and selective small molecule agonist of Toll-like receptor 8 (TLR8), exhibiting an EC50 of 100 nM and over 50-fold selectivity against TLR7. It is utilized in immunological research to study innate immune activation and has been investigated in preclinical models for its potential in cancer immunotherapy and as a vaccine adjuvant.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 926927-61-9
• MW: 458.61
• Purity: >98%
• Formula: C₂₈H₃₄N₄O₂
• SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1ccc(cc1)C(=O)N1CCCC1
• Target: TLR (Toll-like receptor)
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VTX-2337

Quick Database Links

Gene Symbol

TLR (Toll-like receptor)