MRT67307

SKU: orb1310941

Description

MRT67307 is a potent kinase inhibitor targeting TBK1, IKKε, SIKs, and ULK1/2, thereby blocking autophagy. It modulates innate immune responses in macrophages by suppressing IRF3 phosphorylation and IFN-β while enhancing TLR-induced IL-10 and IL-1ra. This tool compound is widely used in autophagy and immunology research, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1190378-57-4
• MW: 464.6
• Purity: 99.25% (May vary between batches)
• Formula: C₂₆H₃₆N₆O₂
• SMILES: O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1
• Target: IκB/IKK,Autophagy
• Solubility: Ethanol:83 mg/mL (178.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.1 mM);DMSO:120 mg/mL (258.29 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IκB, IkB, IkB/IKK, IKK, IKKϵ, IKKε, MRT 67307, MRT67307, MRT-67307, MRT67307 HCl, Autophagy, ULK2, ULK1, ULK, transduction, signal, TBK1, TBK-1

Quick Database Links

Gene Symbol

IκB/IKK,Autophagy