MYCi975

SKU: orb1219642

Description

MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1].The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability.

Key Properties

• CAS Number: 2289691-01-4
• MW: 561.3
• Purity: >98% (HPLC)
• Formula: C₂₅H₁₆Cl₂F₆N₂O₂
• SMILES: Cn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(-c2ccc(Cl)c(c2)C(F)(F)F)c1O)C(F)(F)F
• Target: c-Myc
• Solubility: DMSO:247 mg/mL (440.05mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NUCC-0200975

Quick Database Links

Gene Symbol

c-Myc