N-Desmethylclozapine

SKU: orb1302043

Description

N-Desmethylclozapine is a bioactive metabolite of clozapine, functioning as a potent 5-HT2C receptor antagonist (IC50: 7.1 nM), a dopamine D4 receptor antagonist, and a δ-opioid receptor agonist. It is a valuable research tool for investigating neuropsychiatric disorders and receptor pharmacology in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6104-71-8
• MW: 312.8
• Purity: 97.25% (May vary between batches)
• Formula: C₁₇H₁₇ClN₄
• SMILES: Clc1ccc2N=c3ccccc3=C(Nc2c1)N1CCNCC1
• Target: 5-HT Receptor,Virus Protease,Drug Metabolite,Dopamine Receptor,Opioid Receptor,AChR
• Solubility: DMSO:125 mg/mL (399.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.39 mM);Ethanol:30 mg/mL (95.91 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5-HT2C, 5HT Receptor, DrugMetabolite, Dopamine Receptor, Drug Metabolite, DopamineReceptor, Desmethylclozapine, D4, Inhibitor, Normethylclozapine, Norclozapine, Muscarinic acetylcholine receptor, N Desmethylclozapine, inhibit, NDesmethylclozapine, N-Desmethylclozapine, mAChR, Opioid Receptor, OpioidReceptor, δ-opioid receptor, Virus Protease, VirusProtease

Quick Database Links

Gene Symbol

5-HT Receptor,Virus Protease,Drug Metabolite,Dopamine Receptor,Opioid Receptor,AChR