Naratriptan hydrochloride

SKU: orb1222699

Description

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 143388-64-1
• MW: 371.93
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₅N₃O₂S·HCl
• SMILES: CNS(=O)(=O)CCc1cc2c(cc1)[nH]cc2C1CCN(CC1)C.Cl
• Target: 5-HT1
• Solubility: DMSO : ≥ 35 mg/mL; 94.10 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Naratriptan HCl | Amerge | Naramig | GR-85548A

Quick Database Links

Gene Symbol

5-HT1