ABT-263

SKU: orb1306480

Description

Navitoclax (ABT-263) is an orally bioavailable small molecule that potently inhibits Bcl-2, Bcl-xL, and Bcl-w (Ki<1 nM), inducing apoptosis. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cellular assays and in vivo xenograft models for studying programmed cell death mechanisms.

Research Area

Cell Biology, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 923564-51-6
• MW: 974.6
• Purity: >98%
• Formula: C₄₇H₅₅ClF₃N₅O₆S₃
• SMILES: C(C1=C(CCC(C)(C)C1)C2=CC=C(Cl)C=C2)N3CCN(CC3)C4=CC=C(C(NS(=O)(=O)C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C=C5)=O)C=C4
• Target: Bcl-2
• Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Navitoclax

Quick Database Links

Gene Symbol

Bcl-2