Nazartinib

SKU: orb1304136

Description

Nazartinib (EGF816) is an irreversible, mutant-selective EGFR inhibitor. It potently and selectively targets common activating mutations (L858R, ex19del) and the T790M resistance mutation, showing significant selectivity over wild-type EGFR in biochemical and cellular assays. Its research applications include in vitro mechanistic studies and in vivo models of non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1508250-71-2
• MW: 495.02
• Purity: ≥95% (May vary between batches)
• Formula: C₂₆H₃₁ClN₆O₂
• SMILES: CN(C)C\C=C\C(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12
• Target: EGFR
• Solubility: Ethanol:92 mg/mL (185.85 mM);DMSO:92 mg/mL (185.85 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGF 816, EGFR, EGF-816, EGF816, EGFR (mutant), Epidermal growth factor receptor, ErbB-1, HER1, Inhibitor, inhibit, Nazartinib, NVS 816, NVS816, NVS-816

Quick Database Links

Gene Symbol

EGFR