NF-κB-IN-1

SKU: orb1298366

Description

NF-κB-IN-1 is a synthetic 4-arylidene curcumin analog that acts as a potent inhibitor of the NF-κB signaling pathway by directly targeting IKK. This compound has demonstrated efficacy in vitro by reducing the viability and clonogenic growth of lung cancer cells such as A549.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1227098-15-8
• MW: 530.57
• Purity: 99.03% (May vary between batches)
• Formula: C₃₁H₃₀O₈
• SMILES: COc1ccc(\C=C\C(=O)C(=Cc2ccc(O)c(OC)c2)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC
• Target: IκB/IKK,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.77 mM);DMSO:40 mg/mL (75.39 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

crucumin, A549, 4-arylidene, 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-, cancer, I kappa B kinase, IκB kinase, IκB, inhibit, IkB, IkB/IKK, IKK, Inhibitor, NFκBIN1, NF-κB-IN-1, NF-κB, NFκB, NF-kB-IN-1, NFkB, NF-kB, NF κB IN 1, NF-kappaB-IN-1, pathway, signaling

Quick Database Links

Gene Symbol

IκB/IKK,NF-κB