Nilotinib monohydrochloride monohydrate

SKU: orb1306342

Description

Nilotinib monohydrochloride monohydrate is a potent second-generation BCR-ABL tyrosine kinase inhibitor effective against numerous mutant forms. It is widely used in biochemical and cellular research to study kinase inhibition, resistance mechanisms, and in preclinical models of chronic myeloid leukemia.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 923288-90-8
• MW: 583.99
• Purity: 99.70% (May vary between batches)
• Formula: C₂₈H₂₂F₃N₇O.HCl.H₂O
• SMILES: O.Cl.Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
• Target: Autophagy,Bcr-Abl
• Solubility: DMSO:45 mg/mL (77.06 mM);10% DMSO+90% Corn Oil:4 mg/mL (6.85 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

tyrosine kinase, inhibit, Nilotinib, Nilotinib (monohydrochloride monohydrate), Nilotinib monohydrochloride, Nilotinib monohydrochloride Monohydrate, Nilotinib monohydrochloride monohydrate, Inhibitor, Autophagy, antitumor, AMN-107, AMN107 (monohydrochloride monohydrate), AMN107 monohydrochloride, AMN107, AMN 107, BcrAbl, Bcr-Abl

Quick Database Links

Gene Symbol

Autophagy,Bcr-Abl