Niraparib tosylate

SKU: orb1300371

Description

Niraparib tosylate is a potent and selective inhibitor of PARP1 and PARP2 enzymes, exhibiting IC50 values of 3.8 nM and 2.1 nM, respectively. It is widely used in cancer research, particularly for studying synthetic lethality in BRCA-deficient models, and has demonstrated efficacy in both in vitro cellular assays and in vivo tumor xenograft studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1038915-73-9
• MW: 492.59
• Purity: 98.19% (May vary between batches)
• Formula: C₁₉H₂₀N₄O·C₇H₈O₃S
• SMILES: Cc1ccc(cc1)S(O)(=O)=O.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1
• Target: PARP,Apoptosis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:91 mg/mL (184.74 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

damage, DNA, breast, Apoptosis, anti-tumor, bioavailable, cancer, Inhibitor, inhibit, lung, poly ADP ribose polymerase, ovarian, Niraparib tosylate, Niraparib Tosylate, Niraparib, Niraparib (MK-4827) tosylate, Niraparib (MK-4827) Tosylate, orally, PARP, PARP1, PARP2, MK 4827, MK 4827 tosylate, MK 4827 Tosylate, MK4827, MK-4827, MK-4827 (tosylate), MK4827 Tosylate, MK-4827 Tosylate

Quick Database Links

Gene Symbol

PARP,Apoptosis