Nitazoxanide

SKU: orb1224663

Description

Nitazoxanide, also known by the brand name Alinia, is a synthetic nitrothiazolyl-salicylamide derivative and an anti-protozoal agent. It is approved for treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. Following oral administration it is rapidly hydrolyzed to its active metabolite, tizoxanide, which is 99% protein bound. Peak concentrations are observed 1-4 hours after administration. It is excreted in the urine, bile and feces. Untoward effects include abdominal pain, vomiting and diarrhea. (In Vitro):Giardia lamblia, a flagellated protozoan, is the most common causative agent of persistent diarrhea worldwide.Nitazoxanide exhibits effect on G. lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM.(In Vivo):Nitazoxanide exhibits a wide spectrum of in vivo activity against a broad spectrum of intestinal parasites, such as Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, the apicomplexan Cryptosporidium parvum, and enteric bacteria infecting animals and humans.Nitazoxanide (50, 75 or 100 mg/kg/day; administered daily by intragastric for up to 25 days) reduces the mortality of Japanese encephalitis virus (JEV) strain-infected mice and protected mice from a lethal dose challenge of JEV.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55981-09-4
• MW: 307.28
• Purity: >98% (HPLC)
• Formula: C₁₂H₉N₃O₅S
• SMILES: CC(OC1=CC=CC=C1C(NC2=NC=C([N+]([O-])=O)S2)=O)=O
• Target: PFOR
• Solubility: DMSO: 62 mg/mL (201.77 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 697855 | NTZ

Quick Database Links

Gene Symbol

PFOR