NS309

SKU: orb1222579

Description

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

Key Properties

• CAS Number: 18711-16-5
• MW: 231.04
• Purity: >98% (HPLC)
• Formula: C₈H₄Cl₂N₂O₂
• SMILES: Clc2ccc1c(NC(=O)C1=NO)c2Cl
• Target: ROS
• Solubility: DMSO : ≥ 50 mg/mL; 216.41 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NS309 | NS-309 | NS 309

Quick Database Links

Gene Symbol

ROS