NS3861

SKU: orb1298032

Description

NS3861 is a high-affinity agonist selectively targeting heteromeric α3β4 and α4β2 nicotinic acetylcholine receptors, yet it uniquely fails to activate α4-containing subtypes. This functional selectivity, influenced by specific β-subunits and a key serine residue, makes it a valuable research tool for studying nAChR pharmacology and neurobiology in both in vitro and in vivo models.

Research Area

Neuroscience

Key Properties

• CAS Number: 216853-59-7
• MW: 284.22
• Purity: 99.40% (May vary between batches)
• Formula: C₁₂H₁₄BrNS
• SMILES: CN1C2CCC1C=C(C2)c1sccc1Br
• Target: AChR
• Solubility: DMSO:100 mg/mL (351.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.07 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pharmacology, α4β2 nAChR, α3β4 nAChR, NS3861, NS-3861, NS 3861, Inhibitor, inhibit, Patch Clamp, nAChR, Nicotinic acetylcholine receptors, Heteromeric

Quick Database Links

Gene Symbol

AChR