Olafertinib

SKU: orb1296096

Description

Olafertinib (RX-518) is an oral, irreversible, and mutant-selective EGFR inhibitor designed to target T790M-mediated resistance in non-small cell lung cancer (NSCLC). It demonstrates potent activity in both cellular assays and in vivo xenograft models, supporting its investigation as a therapeutic agent for EGFR-mutant NSCLC.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1660963-42-7
• MW: 530.57
• Purity: 98.43% (May vary between batches)
• Formula: C₂₉H₂₈F₂N₆O₂
• SMILES: OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.54 mM);DMSO:120 mg/mL (226.17 mM);H2O:Insoluble

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK 101, CK101, CK-101, EGFR, EGFR (T790M), EGFR-IN-3, Epidermal growth factor receptor, ErbB-1, HER1, Inhibitor, Olafertinib, NSCLC, inhibit, RX 518, RX518, RX-518

Quick Database Links

Gene Symbol

EGFR