Olverembatinib dimesylate

SKU: orb1305496

Description

Olverembatinib dimesylate is an orally active small molecule inhibitor targeting both wild-type Bcr-Abl and the T315I mutant. It is used in research for chronic myeloid leukemia, demonstrating activity in cellular assays and in vivo models of resistant disease.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1421783-64-3
• MW: 724.77
• Purity: 97.66% (May vary between batches)
• Formula: C₂₉H₂₇F₃N₆O·2CH₄O₃S
• SMILES: CS(O)(=O)=O.CS(O)(=O)=O.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1
• Target: Bcr-Abl
• Solubility: DMSO:93 mg/mL (128.32 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:92 mg/mL (126.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.55 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abl, Abl (E255K), Abl (H396P), Abl (M351T), Abl (Q252H), Bcr-Abl, Bcr-Abl(T315I), BcrAbl, breakpoint, cluster, nonphosphorylated, linase, inhibit, imatinib, Olverembatinib, Olverembatinib dimesylate, Olverembatinib Dimesylate, HQP 1351, HQP1351, HQP-1351, HQP1351 dimesylate, Inhibitor, GZD 824, GZD 824 Dimesylate, GZD824, GZD-824, GZD824 Dimesylate, GZD-824 Dimesylate, region-Abelson, phosphorylated, resistance

Quick Database Links

Gene Symbol

Bcr-Abl