Onalespib

SKU: orb1300903

Description

Onalespib (AT13387) is an orally available small molecule Hsp90 inhibitor with antineoplastic potential. It disrupts Hsp90's chaperone function, leading to the degradation of client oncoproteins critical for tumor survival. This compound has demonstrated activity in preclinical studies across various cancer models, supporting its investigation in oncology research.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 912999-49-6
• MW: 409.52
• Purity: 98.05% (May vary between batches)
• Formula: C₂₄H₃₁N₃O₃
• SMILES: CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
• Target: HSP
• Solubility: DMSO:2.04 mg/mL (4.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AT 13387, AT13387, AT-13387, Onalespib, Onalespib (AT13387), inhibit, HSP, HSP90, Inhibitor, Heat shock proteins

Quick Database Links

Gene Symbol

HSP

Romy Cools # 1, Valeria Narykina # 1 2 3, Koen Vermeulen 4, Sanket J Mishra 5, Brian S J Blagg 5 6, Marleen Derweduwe 7 8 9, Frederik De Smet 7 8 9, Aaron Ziani-Zeryouh 10, Matteo Riva 10 11, An Coosemans 10, Frederic Rousseau 2 3, Joost Schymkowitz 2 3, Guy Bormans 12 [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics EJNMMI Radiopharm Chem, (2025)

PubMed: 41003947